Multifactorial condition affecting the prostate and the bladder2,3

  • LUTS associated with BPH can be attributed to multiple factors including an enlarged prostate gland, increased smooth muscle tone within the prostate,
    and/or bladder dysfunction.2,3
  • Symptoms associated with BPH are classified as either obstructive
    or irritative symptoms.2,3
  • The obstructive symptoms—hesitancy/straining, incomplete emptying of the
    bladder, intermittency, and weak stream—are related to bladder emptying.2,3
  • The irritative symptoms—frequency, urgency, and nocturia—are related to
    bladder storage.2,3

LUTS=lower urinary tract symptoms.

BPH negatively
impacts the patient

Men seek medical attention for bothersome symptoms4-6

  • In men with severe symptoms,
    BPH can interfere with normal
    daily activities, sleep, and sexual
  • As the severity of obstructive
    symptoms increases, the overall
    well-being of the patient
    is significantly decreased.10
  • While obstructive symptoms
    of BPH are more common,
    irritative symptoms are more
    bothersome to patients and
    may interfere with
    daily activities.4-6
  • Patients often seek BPH
    treatment due to nocturia,
    frequency, and urgency.4-6

The role of α1A receptors in BPH

α1A blockade may improve both bladder storage and voiding function11

  • Obstructive symptoms in BPH are the result of bladder outlet
    obstruction (BOO) due to prostate enlargement and/or increased
    α1A-adrenergic activity.2,12 α1A receptors regulate smooth muscle
    contraction in the prostate, bladder base and neck, and
    urethra,1,13,14 and blockade of α1A receptors relieves obstructive
    symptoms and improves urine flow.13
  • Voiding symptoms in BPH may be due to increased bladder
    C-fiber activity.11,12
  • α1A receptors modulate bladder C-fiber afferent activity,11,15 and
    bladder storage function may improve with blockade of α1A

*Findings may not correlate with actual clinical outcomes.


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